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In Europe, the downstream paints and coatings sector presented weak demand in front of the titanium dioxide manufacturers, and thus, the titanium dioxide price trend experienced a gradual decline in its trajectory. Additionally, the pressure of inflation and increasing bank interest rates lowered the spending appetite of consumers which had an adverse effect on the titanium dioxide price trends. Further, the export and import of titanium dioxide were also caught under the negative influence of the poor economic conditions of the market.

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In 2017, French researchers from the Institut National de la Recherche Agronomique (INRAE) were among the first to examine the effects of E171 nanoparticles on the body. They fed rats a dose of 10mg of E171 per kilogram of body weight per day, which was similar to human exposure in food. The research, which was published in Scientific Reports, showed that E171 was able to traverse the intestinal barrier, pass into the bloodstream, and reach other areas of the body in rats. Researchers also found a link between immune system disorders and the absorption of titanium dioxide nanoparticles. 

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In recent years, manufacturers have been focusing on improving the efficiency of these processes through technological advancements. For instance, the adoption of nanotechnology has enabled the production of TIO2 nanoparticles, enhancing the performance of end-products while reducing the overall amount needed. Additionally, efforts are being made to develop eco-friendly manufacturing methods, such as recycling TIO2 waste and utilizing renewable energy sources Additionally, efforts are being made to develop eco-friendly manufacturing methods, such as recycling TIO2 waste and utilizing renewable energy sources Additionally, efforts are being made to develop eco-friendly manufacturing methods, such as recycling TIO2 waste and utilizing renewable energy sources Additionally, efforts are being made to develop eco-friendly manufacturing methods, such as recycling TIO2 waste and utilizing renewable energy sourcestio2 procurement manufacturers.

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